Q: What is the link between obesity and endometrial cancer?

Oestrogen is also made in the body fat and the more fat a women has, the more oestrogen is produced. The ovaries stop producing oestrogen and progesterone after the menopause but the body fat continues to produce oestrogen. Under these circumstances, oestrogen acts on the endometrium without the regulating effect of progesterone. High oestrogen levels with little or no progesterone to balance the effects is known as ‘unopposed’ oestrogen production and this is linked to an increased risk of endometrial cancer.

-- See Why does obesity increase the risk of endometrial cancer, by Consultant Gynaecologist, Miss Adeola Olaitan