Ehlers-Danlos syndromes are a group of heritable connective tissue disorders that affect collagen—the most abundant protein in the body. There are thirteen types of EDS described in the current classification criteria, each with a set of core features, ranging from joint hypermobility and skin hyperextensibility to organ and vascular fragility. Hypermobility spectrum disorders (HSD) refer to individuals who experience symptomatic joint hypermobility, but do not meet the current 2017 criteria for a diagnosis of hypermobile EDS.
